Enantioselective synthesis of hydantoins by chiral acid-catalysed condensation of glyoxals and ureas.

ABSTRACT: Hydantoins are important scaffolds in natural products and pharmaceuticals, with only a few synthetic strategies available for their asymmetric preparation. We herein describe a single-step enantioselective synthesis of 5-monosubstituted hydantoins via condensation of glyoxals and ureas in the presence of a chiral phosphoric acid at room temperature. Products were formed in up to 99% yield and 98 : 2 e.r. Using mechanistic and kinetic studies, including time course ¹H NMR monitoring, we revealed that the reaction likely proceeds via face-selective protonation of an enol-type intermediate.

SUBMITTER: Aryal S 

PROVIDER: S-EPMC10370572 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature