Multi-ancestry epigenome-wide analyses identify methylated sites associated with aortic augmentation index in TOPMed MESA.

ABSTRACT: Despite the prognostic value of arterial stiffness (AS) and pulsatile hemodynamics (PH) for cardiovascular morbidity and mortality, epigenetic modifications that contribute to AS/PH remain unknown. To gain a better understanding of the link between epigenetics (DNA methylation) and AS/PH, we examined the relationship of eight measures of AS/PH with CpG sites and co-methylated regions using multi-ancestry participants from Trans-Omics for Precision Medicine (TOPMed) Multi-Ethnic Study of Atherosclerosis (MESA) with sample sizes ranging from 438 to 874. Epigenome-wide association analysis identified one genome-wide significant CpG (cg20711926- CYP1B1 ) associated with aortic augmentation index (AIx). Follow-up analyses, including gene set enrichment analysis, expression quantitative t

SUBMITTER: Manichaikul A 

PROVIDER: S-EPMC10371087 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature