The shared genetic risk architecture of neurological and psychiatric disorders: a genome-wide analysis.

ABSTRACT: While neurological and psychiatric disorders have historically been considered to reflect distinct pathogenic entities, recent findings suggest shared pathobiological mechanisms. However, the extent to which these heritable disorders share genetic influences remains unclear. Here, we performed a comprehensive analysis of GWAS data, involving nearly 1 million cases across ten neurological diseases and ten psychiatric disorders, to compare their common genetic risk and biological underpinnings. Using complementary statistical tools, we demonstrate widespread genetic overlap across the disorders, even in the absence of genetic correlations. This indicates that a large set of common variants impact risk of multiple neurological and psychiatric disorders, but with divergent effect sizes. Furthe

SUBMITTER: Smeland OB 

PROVIDER: S-EPMC10371109 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature