The Cardiovascular Impact and Genetics of Pericardial Adiposity.

ABSTRACT:

Background

While previous studies have reported associations of pericardial adipose tissue (PAT) with cardiovascular diseases such as atrial fibrillation and coronary artery disease, they have been limited in sample size or drawn from selected populations. Additionally, the genetic determinants of PAT remain largely unknown. We aimed to evaluate the association of PAT with prevalent and incident cardiovascular disease and to elucidate the genetic basis of PAT in a large population cohort.

Methods

A deep learning model was trained to quantify PAT area from four-chamber magnetic resonance images in the UK Biobank using semantic segmentation. Cross-sectional and prospective cardiovascular disease associations were evaluated, controlling for sex and age. A genome-wide associatio

SUBMITTER: Ramo JT 

PROVIDER: S-EPMC10371191 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature