Native American genetic ancestry and pigmentation allele contributions to skin color in a Caribbean population.

ABSTRACT: Our interest in the genetic basis of skin color variation between populations led us to seek a Native American population with genetically African admixture but low frequency of European light skin alleles. Analysis of 458 genomes from individuals residing in the Kalinago Territory of the Commonwealth of Dominica showed approximately 55% Native American, 32% African, and 12% European genetic ancestry, the highest Native American genetic ancestry among Caribbean populations to date. Skin pigmentation ranged from 20 to 80 melanin units, averaging 46. Three albino individuals were determined to be homozygous for a causative multi-nucleotide polymorphism OCA2^NW273KV contained within a haplotype of African origin; its allele frequency was 0.03 and single allele effect size was

SUBMITTER: Ang KC 

PROVIDER: S-EPMC10371226 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature