Short-range interactions between fibrocytes and CD8⁺ T cells in COPD bronchial inflammatory response.

ABSTRACT: Bronchi of chronic obstructive pulmonary disease (COPD) are the site of extensive cell infiltration, allowing persistent contact between resident cells and immune cells. Tissue fibrocytes interaction with CD8⁺ T cells and its consequences were investigated using a combination of in situ, in vitro experiments and mathematical modeling. We show that fibrocytes and CD8⁺ T cells are found in the vicinity of distal airways and that potential interactions are more frequent in tissues from COPD patients compared to those of control subjects. Increased proximity and clusterization between CD8⁺ T cells and fibrocytes are associated with altered lung function. Tissular CD8⁺ T cells from COPD patients promote fibrocyte chemotaxis via the CXCL8

SUBMITTER: Eyraud E 

PROVIDER: S-EPMC10371228 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature