Searching for molecular hypoxia sensors among oxygen-dependent enzymes.
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ABSTRACT:
SUBMITTER: Li L
PROVIDER: S-EPMC10371230 | biostudies-literature | 2023 Jul
REPOSITORIES: biostudies-literature
Publications
Searching for molecular hypoxia sensors among oxygen-dependent enzymes.
Li Li L Shen Susan S Bickler Philip P Jacobson Matthew P MP Wu Lani F LF Altschuler Steven J SJ
eLife 20230726
The ability to sense and respond to changes in cellular oxygen levels is critical for aerobic organisms and requires a molecular oxygen sensor. The prototypical sensor is the oxygen-dependent enzyme PHD: hypoxia inhibits its ability to hydroxylate the transcription factor HIF, causing HIF to accumulate and trigger the classic HIF-dependent hypoxia response. A small handful of other oxygen sensors are known, all of which are oxygen-dependent enzymes. However, hundreds of oxygen-dependent enzymes ...[more]
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