Short-term fasting lowers glucagon levels under euglycemic and hypoglycemic conditions in healthy humans.

ABSTRACT: Fasting is associated with increased susceptibility to hypoglycemia in people with type 1 diabetes, thereby making it a significant health risk. To date, the relationship between fasting and insulin-induced hypoglycemia has not been well characterized, so our objective was to determine whether insulin-independent factors, such as counterregulatory hormone responses, are adversely impacted by fasting in healthy control individuals. Counterregulatory responses to insulin-induced hypoglycemia were measured in 12 healthy people during 2 metabolic studies. During one study, participants ate breakfast and lunch, after which they underwent a 2-hour bout of insulin-induced hypoglycemia (FED). During the other study, participants remained fasted prior to hypoglycemia (FAST). As expected, hepatic gl

SUBMITTER: Warner SO 

PROVIDER: S-EPMC10371233 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature