Activated cGAS/STING signaling elicits endothelial cell senescence in early diabetic retinopathy.

ABSTRACT: Diabetic retinopathy (DR) is a leading cause of blindness in working-age adults and remains an important public health issue worldwide. Here we demonstrate that the expression of stimulator of interferon genes (STING) is increased in patients with DR and animal models of diabetic eye disease. STING has been previously shown to regulate cell senescence and inflammation, key contributors to the development and progression of DR. To investigate the mechanism whereby STING contributes to the pathogenesis of DR, diabetes was induced in STING-KO mice and STINGGT (loss-of-function mutation) mice, and molecular alterations and pathological changes in the retina were characterized. We report that retinal endothelial cell senescence, inflammation, and capillary degeneration were all inhibited in STI

SUBMITTER: Liu H 

PROVIDER: S-EPMC10371250 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature