Evaluating the Impact of Statin Use on Influenza Vaccine Effectiveness and Influenza Infection in Older Adults.

ABSTRACT:

Background

Older adults are recommended to receive influenza vaccination annually, and many use statins. Statins have immunomodulatory properties that might modify influenza vaccine effectiveness (VE) and alter influenza infection risk.

Methods

Using the test-negative design and linked laboratory and health administrative databases in Ontario, Canada, we estimated VE against laboratory-confirmed influenza among community-dwelling statin users and nonusers aged ≥66 years during the 2010-2011 to 2018-2019 influenza seasons. We also estimated the odds ratio for influenza infection comparing statin users and nonusers by vaccination status.

Results

Among persons tested for influenza across the 9 seasons, 54 243 had continuous statin exposure before testing and 48 469 were

SUBMITTER: Chung H 

PROVIDER: S-EPMC10371308 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature