Ontology highlight
ABSTRACT:
SUBMITTER: Werner F
PROVIDER: S-EPMC10371345 | biostudies-literature | 2023 Jul
REPOSITORIES: biostudies-literature
Werner Franziska F Prentki Santos Estefania E Michel Konstanze K Schrader Hanna H Völker Katharina K Potapenko Tamara T Krebes Lisa L Abeßer Marco M Möllmann Dorothe D Schlattjan Martin M Schmidt Hannes H Skryabin Boris V BV Špiranec Spes Katarina K Schuh Kai K Denton Christopher P CP Baba Hideo A HA Kuhn Michaela M
JCI insight 20230710 13
Excessive activation of cardiac fibroblasts (CFs) in response to injury provokes cardiac fibrosis, stiffness, and failure. The local mediators counterregulating this response remain unclear. Exogenous C-type natriuretic peptide (CNP) exerts antifibrotic effects in preclinical models. To unravel the role of the endogenous hormone, we generated mice with fibroblast-restricted deletion (KO) of guanylyl cyclase-B (GC-B), the cGMP-synthesizing CNP receptor. CNP activated GC-B/cGMP signaling in human ...[more]