Stool-Based Colorectal Cancer Screening Test Performance Characteristics in Those With and Without Hemorrhoids.

ABSTRACT:

Objective

To evaluate the effect of hemorrhoids on noninvasive stool test performance for colorectal cancer (CRC) screening.

Patients and methods

We conducted a retrospective cohort study of test characteristics for the fecal immunochemical test (FIT) and the multitarget stool DNA (mt-sDNA) test, on the basis of hemorrhoid status, recorded at the time of colonoscopy, among patients enrolled in the pivotal prospective study for mt-sDNA that was conducted from June 2011, to May 2013. Test characteristics (sensitivity, specificity, positive, and negative predictive values) for FIT and mt-sDNA (performed < 90 days before colonoscopy) were stratified by the presence of hemorrhoids and compared.

Results

Hemorrhoids were found in 51.7% (5163 of 9989) of the study cohort. Acr

SUBMITTER: Ebner DW 

PROVIDER: S-EPMC10371761 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature