The role of thioredoxin proteins in Mycobacterium tuberculosis probed by proteome-wide target profiling.

ABSTRACT: Mycobacterium tuberculosis encounters diverse microenvironments, including oxidative assault (ROS and RNS), when it attempts to establish itself within its human host. Therefore, redox sensory and regulation processes are assumed significant importance, as these are essential processes for M. tuberculosis to survive under these hostile conditions. M. tuberculosis contains thioredoxin system to maintain redox homeostasis, which establish a balance between the thiol/dithiol couple. Still very less is known about it. In the present study, we attempted to capture the targets of all the M. tuberculosis thioredoxin proteins (viz., TrxB and TrxC) and a thioredoxin-like protein, NrdH, under aerobic and hypoxic conditions by performing thioredoxin trapping chromat

SUBMITTER: Sugandhi S 

PROVIDER: S-EPMC10371808 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature