Structural and microstructural thalamocortical network disruption in sporadic behavioural variant frontotemporal dementia.

ABSTRACT:

Background

Using multi-block methods we combined multimodal neuroimaging metrics of thalamic morphology, thalamic white matter tract diffusion metrics, and cortical thickness to examine changes in behavioural variant frontotemporal dementia. (bvFTD).

Method

Twenty-three patients with sporadic bvFTD and 24 healthy controls underwent structural and diffusion MRI scans. Clinical severity was assessed using the Clinical Dementia Rating scale and behavioural severity using the Frontal Behaviour Inventory by patient caregivers. Thalamic volumes were manually segmented. Anterior and posterior thalamic radiation fractional anisotropy and mean diffusivity were extracted using Tract-Based Spatial Statistics. Finally, cortical thickness was assessed using Freesurfer. We used shape anal

SUBMITTER: Jakabek D 

PROVIDER: S-EPMC10371821 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature