Ontology highlight
ABSTRACT:
SUBMITTER: Tanaka K
PROVIDER: S-EPMC10372144 | biostudies-literature | 2023 Jul
REPOSITORIES: biostudies-literature
Tanaka Kai K Kawai Shigeto S Fujii Etsuko E Yano Masumi M Miyayama Takashi T Nakano Kiyotaka K Terao Kimio K Suzuki Masami M
Scientific reports 20230726 1
The in-depth analysis of the ADME profiles of drug candidates using in vitro models is essential for drug development since a drug's exposure in humans depends on its ADME properties. In contrast to efforts in developing human in vitro absorption models, only a limited number of studies have explored models using rats, the most frequently used species in in vivo DMPK studies. In this study, we developed a monolayer model with an effective barrier function for ADME assays using rat duodenal organ ...[more]