Sex effects in predictors of smoking abstinence and neuropsychiatric adverse events in the EAGLES trial.

ABSTRACT: Significance There are sex effects in abstinence outcomes across all smoking cessation medications, but there is limited information regarding sex effects on cessation-related neuropsychiatric adverse events (NPSAEs) or interactions with psychiatric status.

Methods

Secondary analysis of data from EAGLES of 8144 adults who smoke cigarettes randomized to varenicline, bupropion, nicotine patch or placebo. Design characteristics included region (within/outside US), psychiatric cohort (absent/present), and treatment. Baseline variables included demographics, smoking history, prior use of study treatments, lifetime suicide-related history, and prior psychiatric co-morbidities and medication use. Design characteristics were forced into logistic regressions models, and then interactions amo

SUBMITTER: McKee SA 

PROVIDER: S-EPMC10372180 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature