Non-shivering thermogenesis is differentially regulated during the hibernation season in Arctic ground squirrels.

ABSTRACT: Arctic ground squirrels are small mammals that experience physiological extremes during the hibernation season. Body temperature rises from 1°C to 40°C during interbout arousal and requires tight thermoregulation to maintain rheostasis. Tissues from wild-caught Arctic ground squirrels were sampled over 9 months to assess the expression of proteins key to thermogenic regulation. Animals were sacrificed while aroused, and the extensor digitorum longus, diaphragm, brown adipose tissue, and white adipose tissue were probed using Western blots to assess protein expression and blood was sampled for metabolite analysis. Significant seasonal expression patterns emerged showing differential regulation. Contrary to our prediction, white adipose tissue showed no expression of uncoupling protein 1, bu

SUBMITTER: Hunstiger M 

PROVIDER: S-EPMC10372343 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature