Estrous cycle state-dependent renewal of appetitive behavior recruits unique patterns of Arc mRNA in female rats.

ABSTRACT:

Introduction

Renewal is a behavioral phenomenon wherein extinction learning fails to generalize between different contextual environments, thereby representing a significant challenge to extinction-based rehabilitative therapies. Previously, we have shown that renewal of extinguished appetitive behavior differs across the estrous cycle of the female rat. In this experiment that effect is replicated and extended upon to understand how the estrous cycle may modulate contextual representation at the neuronal population level to drive renewal.

Methods

Estrous cycle stage [i.e., proestrus (P, high hormone) or metestrus/diestrus (M/D, low hormone)] was considered during two important learning and behavioral expression windows: at extinction training and during long-term memory (LT

SUBMITTER: Hilz EN 

PROVIDER: S-EPMC10372431 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature