Analysis of RBD-ACE2 interactions in livestock species as a factor in the spread of SARS-CoV-2 among animals.

ABSTRACT: The high mutation rate of SARS-CoV-2, which has led to the emergence of a number of virus variants, creates risks of transmission from humans to animal species and the emergence of new animal reservoirs of COVID-19. This study aimed to identify animal species among livestock susceptible to infection and develop an approach that would be possible to use for assessing the hazards caused by new SARS-CoV-2 variants for animals. Bioinformatic analysis was used to evaluate the ability of receptor-binding domains (RBDs) of different SARS-CoV-2 variants to interact with ACE2 receptors of livestock species. The results indicated that the stability of RBD-ACE2 complexes depends on both amino acid residues in the ACE2 sequences of animal species and on mutations in the RBDs of SARS-CoV-2 variants, wi

SUBMITTER: Peka M 

PROVIDER: S-EPMC10372456 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature