Solubility determination, dissolution properties and solid transformation of resmetirom (form A) in heptane and seven alcohols.

ABSTRACT: In this work, the solubility of resmetirom (form A) was initially measured in heptane and seven alcohol solvents by gravimetric methods. Then, the transformation temperature between form A and ethanol solvate was determined at 333.76 K. Subsequently, some commonly used models were applied to fit the solubility data, and it was found that the modified Apelblat equation and the Jouyban-Acree-van't Hoff (J-A-V) model achieved the highest correlation accuracy for those in mono-solvents and heptane + propanol, respectively. And the average relative deviation (ARD) values of models were less than 0.5%, indicating a good agreement with the experimental results. Additionally, through density functional theory calculation and the analysis of solvent parameters, it was observed that hydrogen-bonding

SUBMITTER: Liu C 

PROVIDER: S-EPMC10372540 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature