Migration and division in cell monolayers on substrates with topological defects.

ABSTRACT: Collective movement and organization of cell monolayers are important for wound healing and tissue development. Recent experiments highlighted the importance of liquid crystal order within these layers, suggesting that +1 topological defects have a role in organizing tissue morphogenesis. We study fibroblast organization, motion, and proliferation on a substrate with micron-sized ridges that induce +1 and -1 topological defects using simulation and experiment. We model cells as self-propelled deformable ellipses that interact via a Gay-Berne potential. Unlike earlier work on other cell types, we see that density variation near defects is not explained by collective migration. We propose instead that fibroblasts have different division rates depending on their area and aspect ratio. This mo

SUBMITTER: Kaiyrbekov K 

PROVIDER: S-EPMC10372565 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature