Wrapping anisotropic microgel particles in lipid membranes: Effects of particle shape and membrane rigidity.

ABSTRACT: Cellular engulfment and uptake of macromolecular assemblies or nanoparticles via endocytosis can be associated to both healthy and disease-related biological processes as well as delivery of drug nanoparticles and potential nanotoxicity of pollutants. Depending on the physical and chemical properties of the system, the adsorbed particles may remain at the membrane surface, become wrapped by the membrane, or translocate across the membrane through an endocytosis-like process. In this paper, we address the question of how the wrapping of colloidal particles by lipid membranes can be controlled by the shape of the particles, the particle-membrane adhesion energy, the membrane phase behavior, and the membrane-bending rigidity. We use a model system composed of soft core-shell microgel particle

SUBMITTER: Liu X 

PROVIDER: S-EPMC10372639 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature