ZNF480 influences the prognosis, pathogenesis, and immune microenvironment in patients with lower-grade glioma.

ABSTRACT: ZNF480 has not yet attracted attention in the study of malignant tumors. Therefore, this study attempts to explain the significance of ZNF480 in the pathological process of lower-grade gliomas (LGG) based on large-scale samples from public database sources and in vitro experiments. Reverse transcription quantitative real-time polymerase chain reaction and immunohistochemistry confirmed that ZNF480 was highly expressed at both the mRNA and protein levels in LGG. Prognostic correlation analysis confirmed that the high expression of ZNF480, as an independent pathogenic gene, significantly correlates with poor survival in patients. Furthermore, the expression level of ZNF480 was significantly inhibited in SHG-44 cells treated with ademetionine disulfat

SUBMITTER: Zhu Q 

PROVIDER: S-EPMC10372659 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature