Multigenerational adversity impacts on human gut microbiome composition and socioemotional functioning in early childhood.

ABSTRACT: Adversity exposures in the prenatal and postnatal period are associated with an increased risk for psychopathology, which can be perpetuated across generations. Nonhuman animal research highlights the gut microbiome as a putative biological mechanism underlying such generational risks. In a sample of 450 mother-child dyads living in Singapore, we examined associations between three distinct adversity exposures experienced across two generations-maternal childhood maltreatment, maternal prenatal anxiety, and second-generation children's exposure to stressful life events-and the gut microbiome composition of second-generation children at 2 y of age. We found distinct differences in gut microbiome profiles linked to each adversity exposure, as well as some nonaffected microbiome features (e.g

SUBMITTER: Querdasi FR 

PROVIDER: S-EPMC10372691 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature