Genetic Variants Associated With Hidradenitis Suppurativa.

ABSTRACT:

Importance

Hidradenitis suppurativa (HS) is a common and severely morbid chronic inflammatory skin disease that is reported to be highly heritable. However, the genetic understanding of HS is insufficient, and limited genome-wide association studies (GWASs) have been performed for HS, which have not identified significant risk loci.

Objective

To identify genetic variants associated with HS and to shed light on the underlying genes and genetic mechanisms.

Design, setting, and participants

This genetic association study recruited 753 patients with HS in the HS Program for Research and Care Excellence (HS ProCARE) at the University of North Carolina Department of Dermatology from August 2018 to July 2021. A GWAS was performed for 720 patients (after quality control) with

SUBMITTER: Sun Q 

PROVIDER: S-EPMC10372759 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature