Metabolomic, proteomic, and transcriptomic changes in adults with epilepsy on modified Atkins diet.

ABSTRACT:

Objective

High-fat and low-carbohydrate diets can reduce seizure frequency in some treatment-resistant epilepsy patients, including the more flexible modified Atkins diet (MAD), which is more palatable, mimicking fasting and inducing high ketone body levels. Low-carbohydrate diets may shift brain energy production, particularly impacting neuron- and astrocyte-linked metabolism.

Methods

We evaluated the effect of short-term MAD on molecular mechanisms in adult epilepsy patients from surgical brain tissue and plasma compared to control participants consuming a nonmodified higher carbohydrate diet (n = 6 MAD, mean age = 43.7 years, range = 21-53, diet for average 10 days; n = 10 control, mean age = 41.9 years, range = 28-64).

Results

By metabolomics, there were 13 increa

SUBMITTER: Leitner DF 

PROVIDER: S-EPMC10372873 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature