Ontology highlight
ABSTRACT:
SUBMITTER: Ma L
PROVIDER: S-EPMC10372881 | biostudies-literature | 2023 Jul
REPOSITORIES: biostudies-literature
Ma Leyuan L Hostetler Alexander A Morgan Duncan M DM Maiorino Laura L Sulkaj Ina I Whittaker Charles A CA Neeser Alexandra A Pires Ivan Susin IS Yousefpour Parisa P Gregory Justin J Qureshi Kashif K Dye Jonathan J Abraham Wuhbet W Suh Heikyung H Li Na N Love J Christopher JC Irvine Darrell J DJ
Cell 20230705 15
Chimeric antigen receptor (CAR) T cell therapy effectively treats human cancer, but the loss of the antigen recognized by the CAR poses a major obstacle. We found that in vivo vaccine boosting of CAR T cells triggers the engagement of the endogenous immune system to circumvent antigen-negative tumor escape. Vaccine-boosted CAR T promoted dendritic cell (DC) recruitment to tumors, increased tumor antigen uptake by DCs, and elicited the priming of endogenous anti-tumor T cells. This process was ac ...[more]