Trapping and retaining intermediates in glycosyltransferases.

ABSTRACT: Glycosyltransferases (GTs) attach sugar molecules to a broad range of acceptors, generating a remarkable amount of structural diversity in biological systems. GTs are classified as either "retaining" or "inverting" enzymes. Most retaining GTs typically use an S_Ni mechanism. In a recent article in the JBC, Doyle et al. demonstrate a covalent intermediate in the dual-module KpsC GT (GT107) supporting a double displacement mechanism.

SUBMITTER: Guerin ME 

PROVIDER: S-EPMC10372902 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature