Association of A1AT genetic polymorphism and NSCLC: a case- control study in Egyptian population.

ABSTRACT:

Background

Lung cancer mortality is higher than other forms of cancer. Genetic tendencies in cancer patients have long been known. Given the link between A1ATD and numerous lung disorders, it is worth investigating if this genetic trait is linked to a higher risk of developing LC, as the lung is the most afflicted organ in individuals with severe A1ATD. This study is intended to investigate the possible association between AAT rs17580 and rs8004738 gene polymorphisms and susceptibility to non-small cell lung cancer for early prediction in Egyptians.

Methods

A case-control study was performed on 124 NSCLC cases and 124 healthy controls from 2021 to 2022 in the oncology center of Mansoura University. Peripheral blood was used to obtain genomic DNA. ARMS-PCR was used to genotyp

SUBMITTER: El-Dawa AN 

PROVIDER: S-EPMC10373285 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature