Designing Potent α-Glucosidase Inhibitors: A Synthesis and QSAR Modeling Approach for Biscoumarin Derivatives.

ABSTRACT: Nineteen biscoumarins were synthesized, well-characterized, and evaluated against α-glucosidases in vitro. Of these, six compounds (10, 12, 16, and 17-19) were newly synthesized and not previously reported in the chemical literature. The majority of the synthesized derivatives demonstrated significant inhibitory activity. A quantitative structure-activity relationship (QSAR) model was developed, revealing a strong correlation between the anti-α-glucosidase activity and selected molecular descriptors. Based on this model, two new compounds (18 and 19) were designed, which exhibited the strongest inhibition with IC₅₀ values of 0.62 and 1.21 μM, respectively, when compared to the positive control (acarbose) with an IC_50</

SUBMITTER: Phan TH 

PROVIDER: S-EPMC10373460 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature