Natural killer cell-related prognostic risk model predicts prognosis and treatment outcomes in triple-negative breast cancer.

ABSTRACT:

Background

Natural killer (NK) cells are crucial to the emergence, identification, and prognosis of cancers. The roles of NK cell-related genes in the tumor immune microenvironment (TIME) and immunotherapy treatment are unclear. Triple-negative breast cancer (TNBC) is a highly aggressive malignant tumor. Hence, this study was conducted to develop a reliable risk model related to NK cells and provide a novel system for predicting the prognosis of TNBC.

Methods

NK cell-related genes were collected from previous studies. Based on TCGA and GEO database, univariate and LASSO cox regression analysis were used to establish the NK cell-related gene signature. The patients with TNBC were separated to high-risk and low-risk groups. After that, survival analysis was conducted and the r

SUBMITTER: Liu Z 

PROVIDER: S-EPMC10373504 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature