Effect of Charged Block Length Mismatch on Double Diblock Polyelectrolyte Complex Micelle Cores.

ABSTRACT: Polyelectrolyte complex micelles are hydrophilic nanoparticles that self-assemble in aqueous environments due to associative microphase separation between oppositely charged blocky polyelectrolytes. In this work, we employ a suite of physical characterization tools to examine the effect of charged block length mismatch on the equilibrium structure of double diblock polyelectrolyte complex micelles (D-PCMs) by mixing a diverse library of peptide and synthetic charged-neutral block polyelectrolytes with a wide range of charged block lengths (25-200 units) and chemistries. Early work on D-PCMs suggested that this class of micelles can only be formed from blocky polyelectrolytes with identical charged block lengths, a phenomenon referred to as chain length recognition. Here, we use salt anneal

SUBMITTER: Stevens KC 

PROVIDER: S-EPMC10373519 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature