Respiratory Syncytial Virus Infection Does Not Induce Epithelial-Mesenchymal Transition.

ABSTRACT: Respiratory syncytial virus (RSV) infection does not cause severe disease in most of us despite suffering from multiple RSV infections during our lives. However, infants, young children, older adults, and immunocompromised patients are unfortunately vulnerable to RSV-associated severe diseases. A recent study suggested that RSV infection causes cell expansion, resulting in bronchial wall thickening in vitro. Whether the virus-induced changes in the lung airway resemble epithelial-mesenchymal transition (EMT) is still unknown. Here, we report that RSV does not induce EMT in three different in vitro lung models: the epithelial A549 cell line, primary normal human bronchial epithelial cells, and pseudostratified airway epithelium. We found that RSV increases the cell surface are

SUBMITTER: Talukdar SN 

PROVIDER: S-EPMC10373540 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature