Diversity of dynamic voltage patterns in neuronal dendrites revealed by nanopipette electrophysiology.

ABSTRACT: Dendrites and dendritic spines are the essential cellular compartments in neuronal communication, conveying information through transient voltage signals. Our understanding of these compartmentalized voltage dynamics in fine, distal neuronal dendrites remains poor due to the difficulties inherent to accessing and stably recording from such small, nanoscale cellular compartments for a sustained time. To overcome these challenges, we use nanopipettes that permit long and stable recordings directly from fine neuronal dendrites. We reveal a diversity of voltage dynamics present locally in dendrites, such as spontaneous voltage transients, bursting events and oscillating periods of silence and firing activity, all of which we characterized using segmentation analysis. Remarkably, we find that n

SUBMITTER: Mc Hugh J 

PROVIDER: S-EPMC10373629 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature