Inflammatory profiles in febrile children with moderate and severe malnutrition presenting at-hospital in Uganda are associated with increased mortality.

ABSTRACT:

Background

Children in Africa carry a disproportionate burden of malnutrition and infectious disease. Together, malnutrition and infection are major contributors to global child mortality; however, their collective impact on immune activation are not well described.

Methods

This was a secondary analysis of a prospective cohort study of children hospitalized with acute febrile illness at a single centre in Uganda. We investigated the association between malnutrition (determined using the mid-upper arm circumference, MUAC), immune activation (as measured by inflammatory markers IL-6, IL-8, CXCL10, CHI3L1, sTNFR1, Cystatin C, granzyme B, and sTREM-1), and mortality.

Findings

Of the 1850 children eligible for this secondary analysis, 71 (3.8%) and 145 (11.7%) presented wi

SUBMITTER: Weckman AM 

PROVIDER: S-EPMC10373657 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature