Polymeric Biomaterial Scaffolds for Tumoricidal Stem Cell Glioblastoma Therapy.

ABSTRACT: Glioblastoma (GBM) is the most common primary brain tumor and has a poor prognosis; as such, there is an urgent need to develop innovative new therapies. Tumoricidal stem cells are an emerging therapy that has the potential to combat limitations of traditional local and systemic chemotherapeutic strategies for GBM by providing a source for high, sustained concentrations of tumoricidal agents locally to the tumor. One major roadblock for tumoricidal stem cell therapy is that the persistence of tumoricidal stem cells injected as a cell suspension into the GBM surgical resection cavity is limited. Polymeric biomaterial scaffolds have been utilized to enhance the delivery of tumoricidal stem cells in the surgical resection cavity and extend their persistence in the brain, ultimately increasing

SUBMITTER: Moore KM 

PROVIDER: S-EPMC10373914 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature