MSK1 is required for the beneficial synaptic and cognitive effects of enriched experience across the lifespan.

ABSTRACT: Positive experiences, such as social interaction, cognitive training and physical exercise, have been shown to ameliorate some of the harms to cognition associated with ageing. Animal models of positive interventions, commonly known as environmental enrichment, strongly influence neuronal morphology and synaptic function and enhance cognitive performance. While the profound structural and functional benefits of enrichment have been appreciated for decades, little is known as to how the environment influences neurons to respond and adapt to these positive sensory experiences. We show that adult and aged male wild-type mice that underwent a 10-week environmental enrichment protocol demonstrated improved performance in a variety of behavioural tasks, including those testing spatial working an

SUBMITTER: More L 

PROVIDER: S-EPMC10373962 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature