Aberrant age-related alterations in spontaneous cortical activity in participants with cerebral palsy.

ABSTRACT:

Introduction

Cerebral Palsy (CP) is the most common neurodevelopmental motor disability, resulting in life-long sensory, perception and motor impairments. Moreover, these impairments appear to drastically worsen as the population with CP transitions from adolescents to adulthood, although the underlying neurophysiological mechanisms remain poorly understood.

Methods

We began to address this knowledge gap by utilizing magnetoencephalographic (MEG) brain imaging to study how the amplitude of spontaneous cortical activity (i.e., resting state) is altered during this transition period in a cohort of 38 individuals with spastic diplegic CP (Age range = 9.80-47.50 years, 20 females) and 67 neurotypical controls (NT) (Age range = 9.08-49.40 years, Females = 27). MEG data from a fiv

SUBMITTER: Bergwell H 

PROVIDER: S-EPMC10374009 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature