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New failure mechanism for evaluating ultimate inclined load adjacent to slope.

ABSTRACT: A new failure mechanism is proposed for calculating the ultimate inclined load adjacent to the slope, i.e., the slope is in the limit state when the critical slope contour and the slope surface are at the critical position where two intersections will occur. The conventional view is that the critical slope contour calculated by the method of characteristics has only a concave shape. This study found that the critical slope contour changes from concave to convex when the inclined load imposed on the slope top surface increases. The feasibility of the proposed method is verified by the finite element limit analysis (FELA) and the definition of the ultimate load. The parametric analysis showed that the current method of characteristics (CMOC) overestimated the ultimate inclined load and gave an incorrect conclusion since it assumed larger failure models at a low strength ratio or large friction angle. The proposed method does not require assumption or search of the failure models, and it can solve the shortcomings of CMOC.

SUBMITTER: Fang H

PROVIDER: S-EPMC10374118 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

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New failure mechanism for evaluating ultimate inclined load adjacent to slope.

Fang Hongwei H Wang Ning N Xu Yixiang Y

PloS one 20230727 7

A new failure mechanism is proposed for calculating the ultimate inclined load adjacent to the slope, i.e., the slope is in the limit state when the critical slope contour and the slope surface are at the critical position where two intersections will occur. The conventional view is that the critical slope contour calculated by the method of characteristics has only a concave shape. This study found that the critical slope contour changes from concave to convex when the inclined load imposed on ...[more]

PMID: 37498816

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Project description:AimsHeart failure (HF) leads to an imbalance between heart and kidney function, resulting in poor outcomes. However, the prognostic significance of the estimated glomerular filtration rate (eGFR) trajectory in HF patients remains unclear. We analysed electronic health records (EHRs) of real-world HF patients, assessing eGFR trajectories and their impact on mortality.Methods and resultsRetrospective clinical data of HF patients were processed using natural language processing. Chronic kidney disease (CKD) was evaluated, and eGFR trajectories were analysed using linear mixed-effects models. Cox proportional hazard models were used to evaluate the relationship between baseline variables and mortality, while joint modelling combined eGFR trends and mortality. The dataset comprised 1986 patients, with a mean age of 74.8 years (SD ± 11.7) and 58% male. At the time of HF diagnosis, 58% of patients were diagnosed with CKD, and 39% presented with heart failure with preserved ejection fraction (HFpEF). The median follow-up duration was 3.16 years, during which 399 patients (20%) died. Patients with CKD were significantly older and exhibited a higher prevalence of myocardial infarction (P = 0.048), coronary revascularization (P = 0.004), stroke (P < 0.001), atrial fibrillation (P < 0.001) and type 2 diabetes (P < 0.001). Mortality rates at 1 and 2 years were nearly twice as high in CKD patients compared with those without (P < 0.001). Notably, CKD was significantly less prevalent among survivors (55% vs. 71%, P < 0.001). Key predictors of mortality included older age, beta-blocker use, prior stroke, lower serum haemoglobin levels, and elevated potassium and NT-proBNP levels. Each 10 mL/min/1.73 m2 decrease in eGFR was associated with a 1.22 (95% CI: 1.10-1.35, P < 0.001) increase in mortality hazard. Additionally, a 1-year decline of 10 mL/min/1.73 m2 in eGFR resulted in a mortality hazard of 1.97 (95% CI: 1.45-2.69, P < 0.001).ConclusionsCKD is prevalent in a real-world HF population and is an independent predictor of mortality. The current eGFR value and the eGFR slope from the previous year have the potential to be used for assessing individual mortality risk in the clinical follow-up of HF patients.

Dataset Information

New failure mechanism for evaluating ultimate inclined load adjacent to slope.

Publications

New failure mechanism for evaluating ultimate inclined load adjacent to slope.

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