Immunogenicity of Bacillus Calmette-Guerin in pigs: potential as a translational model of non-specific effects of BCG.

ABSTRACT:

Background

Clinical and immunological studies in humans show that the live attenuated Bacillus Calmette-Guérin (BCG) vaccine has beneficial non-specific effects, increasing resistance against diseases other than tuberculosis. The underlying mechanisms are currently being explored. The pig exhibits considerable physiological similarity to humans in anatomy and physiology, suggesting that similar responses to BCG could be expected. Studies of the non-specific effects of BCG in pigs are scarce. We investigated the feasibility of using pigs as a large animal model to investigate the non-specific immunological effects of BCG.

Methods

In a series of experiments, we randomized newborn or young piglets from conventional farms to receiving BCG or placebo and investigated the p

SUBMITTER: Jensen KJ 

PROVIDER: S-EPMC10374211 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature