Association of psychological distress, smoking and genetic risk with the incidence of lung cancer: a large prospective population-based cohort study.

ABSTRACT:

Background

Emerging evidence suggests a potential link between psychological distress (anxiety and depression) and lung cancer risk, however, it is unclear whether other factors such as tobacco smoking and genetic susceptibility modify the association.

Methods

We included 405,892 UK Biobank participants free of cancer at baseline. Psychological distress was measured using the Patient Health Questionnaire-4 (PHQ-4). A polygenic risk score (PRS) was calculated using 18 lung cancer-associated genetic loci. Multivariable Cox regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).

Results

During a median follow-up of 7.13 years, 1754 lung cancer cases were documented. The higher score of psychological distress was associated with an

SUBMITTER: Zhang J 

PROVIDER: S-EPMC10374306 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature