DREAM: an R package for druggability evaluation of human complex diseases.

ABSTRACT:

Motivation

De novo drug development is a long and expensive process that poses significant challenges from the design to the preclinical testing, making the introduction into the market slow and difficult. This limitation paved the way to the development of drug repurposing, which consists in the re-usage of already approved drugs, developed for other therapeutic indications. Although several efforts have been carried out in the last decade in order to achieve clinically relevant drug repurposing predictions, the amount of repurposed drugs that have been employed in actual pharmacological therapies is still limited. On one hand, mechanistic approaches, including profile-based and network-based methods, exploit the wealth of data about drug sensitivity and perturbational profiles as

SUBMITTER: Federico A 

PROVIDER: S-EPMC10374489 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature