Zn²⁺ incorporated composite polysaccharide microspheres for sustained growth factor release and wound healing.

ABSTRACT: The development of new wound dressings has always been an issue of great clinical importance and research promise. In this study, we designed a novel double cross-linked polysaccharide hydrogel microspheres based on alginate (ALG) and hyaluronic acid methacrylate (HAMA) from gas-assisted microfluidics for wound healing. The microspheres from gas-assisted microfluidics showed an uniform size and good microsphere morphology. Moreover, this composite polysaccharide hydrogel microspheres were constructed by harnessing the fact that zinc ions (Zn²⁺) can cross-link with ALG as well as histidine-tagged vascular endothelial growth (His-VEGF) to achieve long-term His-VEGF release, thus promoting angiogenesis and wound healing. Meanwhile, Zn²⁺, as an important trace element, ca

SUBMITTER: Ju Y 

PROVIDER: S-EPMC10374596 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature