β-CATENIN is a positive prognostic marker for HPV-positive head and neck squamous cell carcinoma.

ABSTRACT:

Purpose

The evolutionary-conserved Wnt/β-CATENIN (WBC) pathway has been implicated in the pathogenesis of different solid malignant tumors. We evaluated the prognostic relevance of β-CATENIN, a pivotal mediator of WBC activation, in patients with human papillomavirus (HPV)-positive head and neck squamous cell carcinoma (HNSCC).

Methods

We analyzed if patients with HPV-positive HNSCC from the "The Cancer Genome Atlas" (TCGA cohort, n = 41) can be stratified based on their CTNNB1 mRNA expression. Moreover, in a tissue microarray (TMA) of primary tumor sections from HPV-positive HNSCC patients treated in a tertiary academic center (in-house cohort, n = 31), we evaluated the prognostic relevance of β-CATENIN expression on protein level.

Results

In silico mining of CTNNB1

SUBMITTER: Stoiber S 

PROVIDER: S-EPMC10374714 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature