Oxathiazinane derivatives display both antineoplastic and antibacterial activity: a structure activity study.

ABSTRACT:

Purpose

The Oxathiazinane substance class is characterized by a high diversity of chemical structures yet to be fully investigated. Our research group recently proved that the 1.4.5-oxathiazine-4.4-dioxide, known as substance GP-2250, possesses antineoplastic properties as shown on pancreatic carcinoma. This current study aims to gain insights into the structure and activity relationship of a series of different Oxathiazinanes regarding their antineoplastic activity and the potential correlation with antibacterial activity. We investigated the newly synthesized Oxathiazinane derivatives: 2255, 2256, 2287, 2289, 2293 and 2296 in comparison to GP-2250.

Methods

The antineoplastic effect was evaluated in different cancer entities (breast, skin, pancreas and colon cancer cell lin

SUBMITTER: Majchrzak-Stiller B 

PROVIDER: S-EPMC10374762 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature