MYD88^L265P and MYD88^other variants show different molecular characteristics and prognostic significance in diffuse large B-cell lymphoma.

ABSTRACT:

Purpose

This study aims to investigate the clinical and molecular differences between diffuse large B-cell lymphoma (DLBCL) patients with MYD88^L265P and MYD88^other.

Methods

DLBCL patients with MYD88 variations were collected from the Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College (CHCAMS), and Suzhou Municipal Hospital from February 6th, 2007 to May 20th, 2022. Clinicopathological parameters and treatment outcomes between MYD88^L265P and MYD88^other were investigated.

Results

A total of 132 patients with MYD88 variations from a cohort of 475 DLBCL patients were included, among which, 78 were MYD88^L265P, while 54 were MYD88^other. MYD88^L265P was more common in

SUBMITTER: Qin Y 

PROVIDER: S-EPMC10374827 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature