Prognostic value of neutrophil extracellular trap signature in clear cell renal cell carcinoma.

ABSTRACT:

Introduction

Clear cell renal cell carcinoma (ccRCC) is the most prevalent type of urological carcinoma. Although targeted therapy and immunotherapy are usually employed, they often result in primary and acquired resistance. There is currently a lack of dependable biomarkers that can accurately anticipate the prognosis of ccRCC. Recent research has indicated the critical role of neutrophil extracellular traps (NETs) in the development, metastasis, and immune evasion of cancer. The aim of this study was to explore the value of NETs in the development and prognosis of ccRCC.

Methods

Clinical features and genetic expression information of ccRCC patients were acquired from The Cancer Genome Atlas (TCGA), International Cancer Genome Consortium (ICGC) and E-MTAB-1980 database. NET

SUBMITTER: Li R 

PROVIDER: S-EPMC10374836 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature