Wide-field optical coherence tomography for microstructural analysis of key tissue types: a proof-of-concept evaluation.

ABSTRACT: Introduction: The presence of positive margins following tumor resection is a frequent cause of re-excision surgery. Nondestructive, real-time intraoperative histopathological imaging methods may improve margin status assessment at the time of surgery; optical coherence tomography (OCT) has been identified as a potential solution but has not been tested with the most common tissue types in surgical oncology using a single, standardized platform. Methods: This was a proof-of-concept evaluation of a novel device that employs wide-field OCT (WF-OCT; OTIS 2.0 System) to image tissue specimens. Various cadaveric tissues were obtained from a single autopsy and were imaged with WF-OCT then processed for permanent histology. The quality and resolution of the WF-OCT images were evalua

SUBMITTER: Rabindran B 

PROVIDER: S-EPMC10374948 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature