Prevalence of neurocognitive disorder in Huntington's disease using the Enroll-HD dataset.

ABSTRACT:

Background

Cognitive decline in Huntington's disease (HD) begins early in the disease course, however the reported prevalence and severity of cognitive impairment varies based on diagnostic approach. A Movement Disorders Society Task Force recently endorsed the use of standardized DSM-5-based criteria to diagnose neurocognitive disorder (NCD) in Huntington's disease.

Objectives

To determine the prevalence and severity of cognitive impairment across different stages of HD by applying NCD criteria (mild and major) to participant data from the Enroll-HD database.

Methods

Enroll-HD participants were triaged into either premanifest (preHD), manifest or control groups. PreHD was further dichotomized into preHD near or preHD far based on predicted time to diagnosis using the

SUBMITTER: Sierra LA 

PROVIDER: S-EPMC10375015 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature