Sepsis-Induced myocardial dysfunction: heterogeneity of functional effects and clinical significance.

ABSTRACT: Sepsis is a life-threatening disease state characterized by organ dysfunction and a dysregulated response to infection. The heart is one of the many organs affected by sepsis, in an entity termed sepsis-induced cardiomyopathy. This was initially used to describe a reversible depression in ejection fraction with ventricular dilation but advances in echocardiography and introduction of new techniques such as speckle tracking have led to descriptions of other common abnormalities in cardiac function associated with sepsis. This includes not only depression of systolic function, but also supranormal ejection fraction, diastolic dysfunction, and right ventricular dysfunction. These reports have led to inconsistent definitions of sepsis-induced cardiomyopathy. Just as there is heterogeneity amon

SUBMITTER: Shvilkina T 

PROVIDER: S-EPMC10375025 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature